Regione Autonoma della Sardegna e Regione Lombardia
Cooperazione scientifica e tecnologica
nelle aree tematiche biotecnologiche e ICT,
Prog. "Ex Ovo Omnia", Grant n. 26096200 (Dec 2011- Dec 2014)

The Ex Ovo Omnia project is partially funded by the autonomous region of Sardinia and the Lombardy region, as part of the "scientific and technological cooperation projects in the areas of biotechnology, ICT implementing the collaboration between the autonomous region of Sardinia and Lombardy region. The aim of the project is to develop physiological systems for in vitro oocyte maturation in domestic mammals with the purpose of improving the efficiency of assisted reproductive biotechnologies.

The genetic improvement and reproduction of farm animals are, in fact, a crucial aspect for the maintenance of the animals and the economic sustainability of farms. The reproductive biotechnologies, from artificial insemination up to biotechnologies based on the use of embryos, have had and continue to have a major impact in animal husbandry worldwide, especially in developed countries. Ovine, swine and equine are the three species considered in this project.


The project is carried out by Avantea based in Cremona, the University of Sassari and the University of Milan. 

News & Events
On the 29th of October 2012 Ex Ovo Omnia project was presented in Milan. The congress opened to the public, focused on the strategies for improving assisted reproduction in domestic mammals and it was held at the Faculty of Veterinary Medicine, University of Milan.

It was held on the 11th of October 2013 at the Maffei Hall (Chamber of Commerce of Cremona) the conference entitled: From basic research to translational medicine through biotechnology. The event was organized within the two Research and Development programs, Superpig and Ex Ovo Omnia. The conference had as its objective the dissemination of current knowledge in the field of organ transplantation, stem cells and biotechnologies. The event was also delivered live streaming and the recorded event is now available in the video section of the following website (http://www.avantea.it/video.html).


Pubblications in peer reviewed journals 

Dieci C, Lodde V, Franciosi F, Lagutina I, Tessaro I, Modina SC, Albertini DF, Lazzari G, Galli C, Luciano AM. The effect of cilostamide on gap junction communication dynamics, chromatin remodeling, and competence acquisition in pig oocytes following parthenogenetic activation and nuclear transfer. Biol Reprod 2013 Sept 27; 89(3):68. http://www.ncbi.nlm.nih.gov/pubmed/23926281

Ledda S, Bebbere D, Ariu F, Pescatori M. Pau S, Zedda MT, Bogliolo U. Unveiling mRNA changes during meiotic progression and pre-implantation development: help from large animal models. Curr Pharm Des. 2012;18(3):256-63. http://www.ncbi.nlm.nih.gov/pubmed/22229563

Luciano AM, Lodde V, Franciosi F, Tessaro I, Corbani D and Modina SC. 2012. Large-scale chromatin morpho-functional changes during mammalian oocyte growth and differentiation. Eur J Histochem. 2012 Aug 10;56(3):e37. doi: 10.4081/ejh.2012.e37. http://www.ncbi.nlm.nih.gov/pubmed/23027353

Abstracts in conference proceedings 

Dieci C, Franciosi F, Lodde V, Lagutina I, Tessaro I, Modina S, Lazzari G, Luciano AM & Galli C. 2012. Cilostamide sustains gap junction-mediated communication and chromatin remodeling in pig oocytes. In 38th Annual Conference of the International Embryo Transfer Society (IETS), Reprod Fertil Dev. 2011 Dec;24(1):211

Book chapter 
Safety in Assisted Reproductive Technologies: Insights from Gene Expression Studies During Preimplantation Development Daniela Bebbere, Luisa Bogliolo, Federica Ariu, Irma Rosati and Sergio Ledda in the book In Vitro Fertilization - Innovative Clinical and Laboratory Aspects edited by Shevach Friedler, ISBN 978-953-51-0503-9, InTech, April 4, 2012