Valentina Lodde

Associate Professor


Valentina Lodde is an Associate Professor of Animal Anatomy and Physiology, at the Department of Veterinary Medicine and Animal Science, University of Milan, since 2016. She graduated in 2002 in Biotechnology from the University of Milan and earned her PhD degree in Biotechnology applied to Veterinary Science at the same University in 2006. After a period of post-doctoral fellowship in Italy, she joined Professor John Peluso’s Laboratory at the University of Connecticut Health Center (USA), where she completed her post-doctoral training in 2011. Back in Italy, she worked as a researcher at the University of Milan until 2016. She was awarded the L’OREAL-UNESCO for Women in Science National Award in 2006 and received the Marie Curie Career Integration Grant (Individual Fellowship programme) in 2012. Dr Lodde’s research interest focuses on the determinants of mammalian female fertility, particularly the study of oocyte and embryo development. Major topics that characterize her investigations are the study of morphological and functional changes occurring in the nucleus of mammalian oocytes, the study of PGRMC1 function in ovarian somatic cells, oocytes, and preimplantation embryos, and more recently, the role of Reactive Oxygen Species in mammalian oogenesis and embryogenesis.

UNIMI webpage

Recent Peer-reviewed Research Publications (last 5 years)

  1. Dey P, Monferini N, Donadini L, Lodde V, Franciosi F, Luciano AM. Method of Isolation and In Vitro Culture of Primordial Follicles in Bovine Animal Model. Methods Mol Biol 2024; 2770:171-182.
  2. Nenonene EK, Trottier-Lavoie M, Marchais M, Bastien A, Gilbert I, Macaulay AD, Khandjian EW, Luciano AM, Lodde V, Viger R, Robert C. Roles of the cumulus-oocyte transzonal network and the Fragile X protein family in oocyte competence. Reproduction 2023; 165:209-219.
  3. Luciano AM, Franciosi F, Dey P, Ladron De Guevara M, Monferini N, Bonumallu SKN, Musmeci G, Fagali Franchi F, Garcia Barros R, Colombo M, Lodde V. Progress toward species-tailored prematuration approaches in carnivores. Theriogenology 2023; 196:202-213.
  4. Lodde V, Luciano AM, Garcia Barros R, Giovanardi G, Sivelli G, Franciosi F. Review: The putative role of Progesterone Receptor membrane Component 1 in bovine oocyte development and competence. Animal 2023; 17 Suppl 1:100783.
  5. Garcia Barros R, Lodde V, Franciosi F, Luciano AM. A refined culture system of oocytes from early antral follicles promotes oocyte maturation and embryo development in cattle. Reproduction 2023; 165:221-233.
  6. Dellaqua TT, Vigaro RA, Janini LCZ, Dal Canto M, Renzini MM, Lodde V, Luciano AM, Buratini J. Neuregulin 1 (NRG1) modulates oocyte nuclear maturation during IVM and improves post-IVF embryo development. Theriogenology 2023; 195:209-216.
  7. Lodde V, Garcia Barros R, Terzaghi L, Franciosi F, Luciano AM. Insights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division. Cancers (Basel) 2022; 14:5755.
  8. Luciano AM, Barros RG, Soares ACS, Buratini J, Lodde V, Franciosi F. Recreating the Follicular Environment: A Customized Approach for In Vitro Culture of Bovine Oocytes Based on the Origin and Differentiation State. Methods Mol Biol 2021; 2273:1-15.
  9. Lodde V, Luciano AM, Musmeci G, Miclea I, Tessaro I, Aru M, Albertini DF, Franciosi F. A Nuclear and Cytoplasmic Characterization of Bovine Oocytes Reveals That Cysteamine Partially Rescues the Embryo Development in a Model of Low Ovarian Reserve. Animals (Basel) 2021; 11.
  10. Buratini J, Soares ACS, Barros RG, Dellaqua TT, Lodde V, Franciosi F, Dal Canto M, Renzini MM, Luciano AM. Physiological parameters related to oocyte nuclear differentiation for the improvement of IVM/IVF outcomes in women and cattle. Reprod Fertil Dev 2021; 34:27-35.
  11. Terzaghi L, Banco B, Groppetti D, Dall’Acqua PC, Giudice C, Pecile A, Grieco V, Lodde V, Luciano AM. Progesterone receptor membrane component 1 (PGRMC1) expression in canine mammary tumors: A preliminary study. Res Vet Sci 2020; 132:101-107.
  12. Soares ACS, Sakoda JN, Gama IL, Bayeux BM, Lodde V, Luciano AM, Buratini J. Characterization and control of oocyte large-scale chromatin configuration in different cattle breeds. Theriogenology 2020; 141:146-152.
  13. Soares ACS, Marques KNG, Braganca LGM, Lodde V, Luciano AM, Buratini J. Synchronization of germinal vesicle maturity improves efficacy of in vitro embryo production in Holstein cows. Theriogenology 2020; 154:53-58.
  14. Lodde V, Garcia Barros R, Dall’Acqua PC, Dieci C, Robert C, Bastien A, Sirard MA, Franciosi F, Luciano AM. Zinc supports transcription and improves meiotic competence of growing bovine oocytes. Reproduction 2020; 159:679-691.
  15. Barros RG, Lodde V, Franciosi F, Luciano AM. In Vitro Culture Strategy for Oocytes from Early Antral Follicle in Cattle. J Vis Exp 2020:e61625.
  16. Lodde V, Colleoni S, Tessaro I, Corbani D, Lazzari G, Luciano AM, Galli C, Franciosi F. A prematuration approach to equine IVM: considering cumulus morphology, seasonality, follicle of origin, gap junction coupling and large-scale chromatin configuration in the germinal vesicle. Reprod Fertil Dev 2019; 31:1793-1804.
  17. Terzaghi L, Luciano AM, Dall’Acqua PC, Modina SC, Peluso JJ, Lodde V. PGRMC1 localization and putative function in the nucleolus of bovine granulosa cells and oocytes. Reproduction 2018; 155:273-282.
  18. Luciano AM, Franciosi F, Barros RG, Dieci C, Lodde V. The variable success of in vitro maturation: can we do better? Anim Reprod; 2018: 727-736.